Prepare the Spinach: Heat a non-stick pan over medium-low heat. Add the spinach and sauté for 3-5 minutes until just wilted. Transfer to a plate to cool.

Mix the Dressing: In a large bowl, combine sour cream, mayonnaise, garlic powder, onion powder, salt, and pepper. Mix until creamy.

Combine the Pasta: Cook penne pasta until al dente, about 10-12 minutes. Drain and rinse under cold water. Add pasta to the dressing and stir to coat.

Incorporate Spinach and Artichokes: Chop cooled spinach and fold into the bowl. Add artichoke hearts if using, and mix gently.

Season and Chill: Adjust seasoning to taste. Transfer to an airtight container and refrigerate for at least 4 hours, preferably overnight.

Serve and Enjoy: Stir well before serving. Enjoy as a side dish at gatherings.